Evaluation of cutpoints for phenotypic hypersusceptibility to efavirenz.
نویسندگان
چکیده
Phenotypic assays measure the susceptibility of HIV-1 to antiretroviral drugs, and are used to guide treatment regimen choices. Analyses of baseline predictors of virological failure support the use of a 0.4-fold cutpoint for defining increased susceptibility (hypersusceptibility) to efavirenz in the PhenoSense HIV assay. The enhancement of the virological activity of efavirenz, associated with resistance to reverse transcriptase inhibitors, provides an opportunity to consider mutational and drug interactions in optimizing treatment.
منابع مشابه
Phenotypic susceptibility and virological outcome in nucleoside-experienced patients receiving three or four antiretroviral drugs.
OBJECTIVE To evaluate phenotypic drug susceptibility and non-nucleoside reverse transcriptase inhibitor hypersusceptibility as predictors of the time to virological failure. DESIGN In a randomized clinical trial, phenotypic susceptibility was retrospectively determined among 131 exclusively nucleoside reverse transcriptase inhibitor (NRTI)-experienced patients with baseline HIV-RNA levels gre...
متن کاملHIV-1 genotypic drug-resistance interpretation algorithms need to include hypersusceptibility-associated mutations.
To the Editor—Tozzi et al. [1] recently reported a retrospective study investigating the effect that mutations associated with hypersusceptibility to nonnucleoside reverse-transcriptase inhibitors (NNRTIs) have on the virological response to efa-virenz-based therapies. The authors concluded that " the M41L, M184V, L210W, and T215Y mutations were associated with a better, although transient, vir...
متن کاملAntiretroviral drug susceptibility among drug-naive adults with recent HIV infection in Rakai, Uganda.
OBJECTIVE To analyze antiretroviral drug susceptibility in HIV from recently infected adults in Rakai, Uganda, prior to the availability of antiretroviral drug treatment. METHODS Samples obtained at the time of HIV seroconversion (1998-2003) were analyzed using the GeneSeq HIV and PhenoSense HIV assays (Monogram Biosciences, Inc., South San Francisco, California, USA). RESULTS Test results ...
متن کاملMutations in HIV-1 reverse transcriptase potentially associated with hypersusceptibility to nonnucleoside reverse-transcriptase inhibitors: effect on response to efavirenz-based therapy in an urban observational cohort.
BACKGROUND Hypersusceptibility to nonnucleoside reverse-transcriptase inhibitors (NNRTIs) was described in association with reverse-transcriptase (RT) mutations conferring resistance to nucleoside reverse-transcriptase inhibitors (NRTIs). We evaluated the effect of RT mutations associated with hypersusceptibility to NNRTIs on the response to efavirenz-based therapy. METHODS We analyzed an obs...
متن کاملSuccessful Desensitization Efavirenz in 8 -year-Old HIV-Positive Child
Background & Aims: Allergic reaction is a common side effect of Efavirenz and drug replacement may not be an option to physicians. Here, a successful drug desensitization experiment on an 8-year-old female child over a period of 9 days is reported. Case presentation: The patient was an 8-year old female child with HIV in Kerman, Iran who had been received oral efavirenz together with lamivudine...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- AIDS
دوره 17 16 شماره
صفحات -
تاریخ انتشار 2003